Yes. Hugely.
It was a few years ago. I was at university, living on campus, pouring absolutely everything I had into a degree. It was competitively sought, had a lengthy qualification process to even get selected, was very high stress, high workload, with an incredible dropout rate. I held up ok though with the sort of singlemindedness an autistic is capable of, and got out into the job - only to find it disappointed me completely. Everything fell apart from there. I had been proverbially running on fumes, pushing myself to the limit to make it to probation, and I found it had all been for nothing. The time, the stress, the student loans, moving inland, all the work, all the buildup that what you were doing was worthwhile, that it made a difference and was important work - and it was nothing.
I had some kind of breakdown - they tell me it was an autistic regression type scenario. I didn't speak for over a year, and did absolutely nothing but bury myself in my special interest. As in I literally did nothing else. I slept and I pursued my interest. Didn't see anyone, go anywhere (except to get supplies for my interest) and had to be cared for by relatives because I was incapable of doing anything else.
Everything changed from that. And it's changed forever I think, as some things that were getting better until that point (like speaking) have remained difficult.
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Alexithymia - 147 points.
Low-Verbal.