Since it's goldfishy's birthday

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What do you make of this?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408485/

I can't quite put my finger on it.. but so much of it seems familiar for some reason - almost like deja vu. Hmm..

If you bother to give it a read/skim, I am genuinely curious what your thoughts are on it.

PS: Someone on the forums asked a while back if anyone knew of any studies pertaining to endogenous causes of depression in autistic people. As per this study, the vast majority of autistics are sensitive to salicylate acids, and if you go ahead and look that up you'll see that the symptoms include depression (among other things).

Happy Birthday.

dude , this is the umpteenth time you've posted this link , it's not Deja Vu , it's goldfish like memory . I'm pretty sure I gave you the link in the first place.

Happy Birthday dude

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It might be that the research is an obverse of previous research from years ago whereby individuals diagnosed with ASD also experienced somewhat subclinical GI symptoms. Someone simply flipped the research and called it "original."

Happy Birthday!

It's an interesting article and it doesn't really surprise me.

Most of this I hadn't heard in this much detail before. The relation between gut microbiome, behavior and disease is not something I had looked into in particular, but I've heard a few things about it before at university (what I had heard about was mostly a link between gut microbiome and anxiety in mice and gut microbiome as a causative factor in obesity in humans as well as a few more things that were mentioned but not in detail). Some microbiologists speculate that gut microbiome will be an important factor in disease research and treatment but it is not yet well understood. It will likely not be limited to autism.

I didn't think before, that you're not on the right track with your diet based autism treatment (of which I do not remember most details and I do not remember if it entailed anything I thought was questionable), but I still don't think that there's any evidence for how many percent of autistic people your specific method may or may not work.
I do not think it's a bad thing that you shared your method on this forum and I wouldn't claim that there isn't a chance of improving symptoms if anyone wanted to try it. I just think that parents who try unproven and unresearched treatment options on their children should be very careful that they don't include anything potentially harmful to the child both on a physical and a psychological level.

On a personal level, unrelated to gut microbiome, the article was interesting for me to read because most of the risk factors for autism they listed couldn't apply less to me.

Happy Birthday.

Can't look into the link right now... but happy birthday, man, some of your stuff I read here worked really great for me

70%.

As I read and shared 5 years ago, and as this study states, 70% of people on the autism spectrum are sensitive to salicylate acids. Said sensitivity is caused by increased intestinal permeability, which in turn is caused by gut dysbiosis. Treat the gut dysbiosis, treat the problems attributabed to it. This is what causes, or exacerbates, ASD symptoms in 70% of people on the spectrum.

Wait another 5-10 years and there will be plenty more information available on it all for you to digest and make decisions on. I’m not the wait 5-15 years kind of guy so took matters into my own hands. To each their own.

That article is definitely worth reading thoroughly if one has available time to absorb all of its contents.

Happy Birthday!

As I said I do not recall in detail what your treatment is all about but it was a long and tedious list. All of that list is about salicylate acids?
Otherwise no, that it can be shown that salicylate acids are linked to autism does not mean that every aspect of your treatment is relevant for treating autism.

Only the very first thing I did (avoid eating sals/epsom salts on skin to replenish mineral deficiencies & excrete excess acids) is directly related to treating salicylate acid sensitivity. The rest is about cleansing & balancing the gut dysbiosis and healing the intestinal lining. (which in turn reduces the acid sensitivity in the first place since the intestines are no longer as perforated by the overgrowth of yeast/bacteria/??whatever it is) Cleansing & balancing the gut gets your enteric nervous system firing properly & sending the signals up the vagus nerve to the brain to make it function as intended - that part - the role of probiotics - has nothing to do with (afaik) salcylate acids.

It's a multi-pronged problem with a multi-pronged solution that's all interconnected. More than 5 years of treating & controlling my symptoms fairly well is all the proof I need that what I do treats my autism symptoms. I know what foods are likely to be triggers that increase symptoms & then what to do about it to rectify the problem and think/feel/behave better & function as highly as I can.

As for reducing acid levels (stopping consuming them entirely for a while & using epsom salts for the minerals to excrete them) several symptoms were directly improved, most notably: the worst depression of my life that lasted (and worsened) for 5 months was all but completely lifted in 5 days, same for sky high anxiety, Extreme audio sensitivity, and executive functions. I can't recall off hand if other symptoms improved remarkably simply by reducing acid levels - but these ones did after that first step of my journey.