I am a bit of a traveler. And while i do it alone I would desire someone to do it with. I get by.
My first trip was Sacremento, Las Vegas, San Fransisco (over three weeks, a week in each)
Second trip was New Orleans. (pre Katriona)
Third was Napa Valley, San Fran.
Fourth trip was New York.
Last trip was South Island of New Zealand (Christchurch, and Queenstown)
I am a bit of a wanderer, and like just walking around a town.
As in relation to being an aspie, you just need to know your limits and what effects you and to what degree. A private and quiet hotel room is a must, so on the days when it's too much you can just stay and be completely alone. Another good idea I came up with when I was in Las Vegas is to cancel the cleaners for your stay. I.E. let them know that you'll make your own bed and change your own sheets, empty trash. The MGM (where I stayed) said that was ok, and when I was showed to my room they let me know where the laundry chute was and where extra bedding linens were. I had to forgo a few things like the nightly complimentary pillow mints, but it was a comfort knowing that I was going to be the only one there. I don't know how suss hotels might be if you are going to be there longer for a few days however. When I stayed in New Orleans it was for an entire month and the B&B/motel/hotel/tweener bits of everything made sure their cleaners went through at least once a week. Which was fine, I just let them know when I was leaving for the day and they nipped in and did it while i was out.
So, that's the biggest aspie tip I can think of. It all depends on your particular difficulties with your aspie symptoms. If you work with your own bounds, and no what bounds can be stretched and what one's cant, and in what particular ways those can be stretched, and if you do stretch them you are prepared to bare the consequences... then it's gonna be all good.
My biggest fret was New Orleans and New York. Those places I specifically went for the nightlife. I love jazz, so I just made sure that if I went to a jazz bar that I got out when I got overwhelmed and didn't have anything planned for the next day so I could curl up in my hotel room and rockmyself back to comfort. New York was fantastic for the classical music. I saw 4 shows by the metropolitan philharmonic (Tchaikovsky's 1st Violin Concerto was the best one, followed closely by Pictures at an Exhibition). Saw swan lake by the proper ballet (can't remember their official names), but also got to see sleeping beauty and romeo and juliet put on by a few amateur companies and dance schools for a note donation.
So, in summary, know your limits, and know your consequences. So when you reach your limit your plans aren't going to be put out.
Can't think of anything else really. Oh, except I saw Elvis in Las Vegas!! ! HOW COOL IS THAT!?!?!