No link between epidurals and autism, two studies confirm

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The results contradict a study published last October that seemingly connected epidurals among women in California to a slightly increased chance of autism in their children. That study drew widespread criticism and concern from researchers and professional medical societies for its failure to account for confounding factors, such as a family history of psychiatric conditions. In April, a follow-up study in Manitoba, Canada, that controlled for some additional factors found no such association.

The two new studies probe the connection further, using different populations and statistical methods. In one, researchers examined the health records of 388,254 children born in British Columbia, Canada, from 2000 to 2014. Because British Columbia has a central autism assessment network, the majority of children in the study went through the same screening and diagnostic process, which was not true for participants in the earlier studies.

About 1.5 percent of the Canadian children exposed to an epidural went on to be diagnosed with autism, compared with 1.3 percent of unexposed children, suggesting a small association.

But further analyses of the data weakened the finding. To control for some factors, such as maternal genetics and socioeconomic status, for example, the researchers repeated the analysis in women who had multiple births, resulting in at least one child with autism and one without. The women were not more likely to have had an epidural while delivering the autistic child than the non-autistic one, they found.

In another study, researchers analyzed data from 479,178 children born in Denmark from 2006 through 2013. Unlike the other three studies, this analysis controlled for family history of autism and maternal psychiatric history, both of which are linked to an increased likelihood of autism. The researchers found no significant association between autism and epidurals.

All four studies also identified differences between parents who did and did not receive an epidural. For example, people who received an epidural tended to be younger and were more likely to have preeclampsia than those who didn’t — both factors linked to autism. And women who received an epidural were more likely to have a psychiatric condition, and their children were more likely to have a parent with autism. The differences suggest that none of the studies fully eliminated confounding factors, Wong wrote in the commentary.