Sequencing trick identifies brain cells affected by large autism-linked mutation
Quote:
A new method for analyzing gene expression levels in human brain organoids — spheres of cultured brain cells — enables researchers to determine whether DNA mutations linked to autism affect some cell types more than others.
Researchers used the method, called Orgo-Seq, to show that deletions of a chromosomal region called 16p11.2 increase the proportion of immature neurons and neural progenitor cells — early precursors of neurons and glia — in brain organoids. The method also revealed genes in the region that may drive those changes.
16p11.2 deletions can result in neurodevelopmental conditions, including autism.
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Professionally Identified and joined WP August 26, 2013
DSM 5: Autism Spectrum Disorder, DSM IV: Aspergers Moderate Severity
“My autism is not a superpower. It also isn’t some kind of god-forsaken, endless fountain of suffering inflicted on my family. It’s just part of who I am as a person”. - Sara Luterman
25 Jul 2022, 9:22 am
