How does vasopressin affect norepinephrine?

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I seriously don't know, but this may be tied to autistic meltdowns in response to some social stimuli. I am having trouble finding articles describing their interaction.

After doing some intensive scouring, I've found that norepinephrine has an opposing effect upon both oxytocin and vasopressin in the paraventricular nucleus of the hypothalamus. I haven't the foggiest idea whether there are similar interactions elsewhere in the system, though because it's perfectly feasible that this interaction is due strictly to the structure of this area of the hypothalamus. It fits with the calcium/magnesium theory, though, because a poverty of calcium/magnesium is known for triggering an efflux of norepinephrine.

Have no idea but your right that there has to be some neurological/biochemical mechanism that primes a person to a meltdown (which we can defined as an over reaction to some stimulus).

I've started adding 1200 mg adrafinil daily to my meds for the last week to see if a few weeks uses will have better results than single day tests I did in the past.

http://en.wikipedia.org/wiki/Adrafinil

I think it has a norepinephrine agonist effect. Anyway I can detect it has lowered my threshold to be upset with simply things.

Curious. This actually turns my initial line of thinking regarding norepinephrine directly on its noggin. People take calcium/magnesium relieve the effects of meltdowns, which SHOULD have the effect of preventing norepinephrine efflux. I interpreted from this that norepinephrine was the cause of the meltdowns, which now seems completely wrong. If norepinephrine controls the meltdowns, then perhaps taking caffeine (to heighten the release of norepinephrine in the system) in conjunction with a calcium/magnesium supplement (to prevent an efflux and to counter caffeine's effect of decreasing the absorbtion of these minerals) could be the key to keeping these meltdowns under control. As you may have noticed, I have a bias toward non-pharmaceutical approaches to these problems. You could just take a shot of expresso from time to time and seek dietary sources of these minerals.

Oh sorry I got my syntax/logic wrong I guess. The norepinephrine agonist seems to be priming me to more likely have a meltdown. I was assuming "lowered my threshold" meant to increase the likely hold I would have a meltdown.

Oh, no, Machine, no. You got the syntax fine. I just parsed "lowered" as "lowered likelihood." It actually would be the case that a lower threshold would cause a higher likelihood. It just confused me. Okay, now everything is making more sense. I'm getting some results that indicate a possible dependence of magnesium for vasopressin release, but none of the studies I've looked at so far are saying anything about the cental nervous system. I'll keep scouring and scraping, though. However, it's starting to look like calcium and magnesium supplementation could both encourage vasopressin release and curtail the meltdowns caused by norepinephrine efflux.

You guys, do you think it's possible that some autists just have a magnesium and calcium deficit? At many points in my life, I've had insane cravings for milk in spite of its negative side-effects, and milk, ironically enough, is very rich in both of these minerals. Magnesium also seems to enhance the excitory effects of oxytocin in certain regions of the brain.

Man, the pharmaceutical companies would be so pissed if parents were to suddenly start fixing their kids by simply feeding them something other than crap.

I drank half a gallon of milk a day for many years. I think its calcium to magnesium ratio is fairly high and calcium interferes with magnesium absorption. So I have always been under the impression dairy is not the ideal source for magnesium. If am not misstaken alot of natural medicine people hype magnesium as usefull in the treatment of ADHD.

Okay, that's even more interesting, actually. Does this mean that some of the positive results reported by parents upon taking out dairy could be due to improved magnesium absorption? The thing is, though, calcium is supposed to be equally important to magnesium in preventing the sort of norepinephrine efflux that results in meltdowns. Maybe there's something wrong with either calcium or magnesium channels in the brains of some autistic children, then.

As fond as I am of nutritional therapy, by the way, I think that it's relevant that there are also probably genetic precursors to problems with calcium or magnesium channels, so nutritional therapy isn't likely to be a magic medicine, really.