Brain inflamation MAY lead to Autism.

Page 1 of 2 [ 20 posts ]  Go to page 1, 2  Next

Fnord
Veteran
Veteran

Joined: 6 May 2008
Gender: Male
Posts: 60,939
Location:      

12 Oct 2023, 6:50 pm

Brain inflammation in young children may contribute to autism, schizophrenia
By Ernie Mundell, HealthDay News, Oct. 12, 2023 / 3:04 PM

Severe inflammation very early in childhood might hamper the development of key brain cells, perhaps setting the stage for conditions such as autism or schizophrenia, new research suggests.

The origins of many neurodevelopment disorders remain mysterious. But the new study of postmortem brain tissue from children who died between the ages 1 and 5 shows how inflammation affects brain cells.

In their research, the team from the University of Maryland School of Medicine targeted a portion of the brain known as the cerebellum, using a cutting-edge technology called single nucleus RNA sequencing.



Read the complete and unedited article  HERE 



lostonearth35
Veteran
Veteran

User avatar

Joined: 5 Jan 2010
Age: 50
Gender: Female
Posts: 12,826
Location: Lost on Earth, waddya think?

15 Oct 2023, 9:20 pm

Another stupid article basically telling clueless parents yet again why their autistic children are broken defective monsters while we adults get ignored. Of course, most of the replies in the news feed were from antivaxxers who clearly will never have to worry about getting a brain inflammation, because you can't inflame something that's not there.

The world is going to a very hot place in a hand basket and it's all because of NTs and their unshakable beliefs in pseudoscience and religion. :x



blitzkrieg
Veteran
Veteran

Joined: 8 Jun 2011
Age: 115
Gender: Non-binary
Posts: 17,820
Location: The line in the sand

15 Oct 2023, 9:42 pm

lostonearth35 wrote:
Another stupid article basically telling clueless parents yet again why their autistic children are broken defective monsters while we adults get ignored. Of course, most of the replies in the news feed were from antivaxxers who clearly will never have to worry about getting a brain inflammation, because you can't inflame something that's not there.

The world is going to a very hot place in a hand basket and it's all because of NTs and their unshakable beliefs in pseudoscience and religion. :x


Actually, brain inflammation during the formative years of brain development, is well documented to be responsible for global changes in the brain, which sometimes results in neurodevelopmental disorders including but not limited to autism.

The article mentions schizophrenia too, but even disorders such as ADHD or emotional regulation disorders can be caused by brain inflammation (when the cerebellum is affected for example by an environmental toxin or toxins, and which results in damage, the connections to other parts of the brain can be impaired).

Pollution can cause issues of brain inflammation during the developmental stage. So it's not all about vaccines and the article isn't about vaccines.

The brain is delicate and subject to changes in functions based on environmental insults. It is a shame that you equate science with religion.

"In their research, the team from the University of Maryland School of Medicine targeted a portion of the brain known as the cerebellum, using a cutting-edge technology called single nucleus RNA sequencing."

^ Sure sounds like religion. :roll:



Fnord
Veteran
Veteran

Joined: 6 May 2008
Gender: Male
Posts: 60,939
Location:      

16 Oct 2023, 12:52 am

Those who equate science with religion seem to have a very poor understanding of both.

The study was statistical in nature, so I am less inclined to accept it as much as I would even one empirical experiment.

However, the results cannot be discounted on the mere basis of one's own scorn and disbelief.



timf
Veteran
Veteran

User avatar

Joined: 25 Oct 2013
Gender: Male
Posts: 1,119

16 Oct 2023, 8:44 am

I see adding Aspergers to classical autism and calling it a spectrum as motivated by those who make money from "treating" the disabled. I see Aspergers as a simple neurological variant. Those children who have actual brain damage or malformation are in need of special care.

The passions stirred by the vaccination debate do not often allow for consideration of possibilities. For example if a child suffers an adverse vaccination reaction of brain swelling, it might explain the classical autism effects afterwards.

"Inflammation" is too vague a word to be very useful in determining a consequence. However, it may point to further research that could be helpful.



carlos55
Veteran
Veteran

Joined: 5 Mar 2018
Gender: Male
Posts: 1,975

16 Oct 2023, 11:44 am

This is a bit of a no brainier as they say.

Inflammation is commonly found in autistic brains.

Inflammation in general is a natural bio marker in that something is medically wrong with that the person and has a condition that is a pathology rather than a natural difference.

https://www.frontiersin.org/articles/10 ... 00886/full

https://www.health.harvard.edu/newslett ... flammation


_________________
"The reasonable man adapts himself to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore all progress depends upon the unreasonable man."

- George Bernie Shaw


Summer_Twilight
Veteran
Veteran

User avatar

Joined: 13 Sep 2011
Age: 43
Gender: Female
Posts: 5,241

16 Oct 2023, 11:56 am

Is there a link to an empirical article with evidence based practices? This sounds like an interesting read.



Fnord
Veteran
Veteran

Joined: 6 May 2008
Gender: Male
Posts: 60,939
Location:      

16 Oct 2023, 7:27 pm

Summer_Twilight wrote:
Is there a link to an empirical article with evidence based practices? This sounds like an interesting read.
I have been looking for one, but it is the nature of studies that the results of subsequent experiments may be years, or even decades away.



blitzkrieg
Veteran
Veteran

Joined: 8 Jun 2011
Age: 115
Gender: Non-binary
Posts: 17,820
Location: The line in the sand

16 Oct 2023, 7:44 pm

Summer_Twilight wrote:
Is there a link to an empirical article with evidence based practices? This sounds like an interesting read.


There is lots of research into brain inflammation & autism, here is just one scientific paper:

https://www.frontiersin.org/articles/10.3389/fphys.2014.00150/full



Mountain Goat
Veteran
Veteran

Joined: 13 May 2019
Gender: Male
Posts: 14,789
Location: .

16 Oct 2023, 9:35 pm

Regarding the thread title, it is an obvious statement because autism is caused by missing brain connections in the frontal part of the brain, where various hypersensitivities and also certain areas of genuis amongst a few are where during brain development (While the brain is growing), the brain often directs growth into other brain areas of it realises that certain areas are damaged. (Is actually wonderful how the human body does this during development).

Now fits are caused by brain connections shorting so they don't nowhere they are supposed to (Hence the uncontrolled movements). Fortunately the majority of fits are temporary but unfortunately can be fatal in extremes. Fits are not always associated with brain development as some people who may never ever have had a fit, can has a fit due to certain external or internal stresses of situations (E.g. Such as an incorrectly administered or an incorrectly dosed local anaesthetic while at the dentist, where some dentists are not even aware there is a certain measurement of else for a certain body mass size etc, which if too little is administered the patient can feel the pain, but if too much is administered it can lead to fits of cardiac arrest... (Why any had experiences should immediately be followed by a 24 your hospital observation period).

Then we have another brain issue which autism is often misdiagnosed as which is a chemical imbalance in the brain called "Bipolar" where sufferers to from highs to lows. Autism sufferers can also go from highs to lows hence the missdiagnoses. The common notable key difference between the two is that bipolar surferers to from a high to a low in a period of a typical four day cycle (E.g. A low eventually turns into a high four days later etc). Autism sufferers who go from highs to lows due to the brain function rather than a chemical imbalance can go from highs to lows in the same day of even in the same hour. With bipolar it takes a few days for the brain chemicals to change. The good news with bipolar is one can alter the brain chemistry through medication. The importance of correct diagnoses is understated because if autism is misdiagnosed as bipolar, and the patient receives medication, the medication (While the patient is receiving it) actually causes bipolar episodes on top of the natural autism trait, so their lives while on the incorrect medication can be absolutely horrible!

While the vast majority of cases of autism are caused in the development of the brain, it has also been known for those involved in more serious motor accidents to develop autism after the accident. This is due to the damage received to the frontal area of the brain.
(I don't know why autism specifically relates to the frontal area of the brain, but in all the things I have read, they specifically mention that it does. Makes one ask what the other areas of the brain do and what would happen if a patient had an issue with one of these other areas, what the symptoms may be? I have not read anything about this. Next time I visit where I used to live I can ask as a neighbour as she is a brain surgeon, so she might be able to tell me... Though her expertise is in a specific area which I think relates to emergency brain operations? When I was asking her about autism it wasn't her area of expertise though she was highly interested. I also got to talk to another lady who was using an ECM machine on me to check if I had fits. I learned a bit from her as she was able to tell.me what was and what was not possible to monitor in the brain, after I panicked as I thought they could read my thoughts! She was at the forefront of medical technology and she said that she doubted within her lifetime (She was in her 30's) that they would ever be able to do that as the brain has many millions more connections than even the largest computer has and is also a whole lot quicker).


But going back to the title. Yes. It is a given obvious statement as if the brain is inflamed during development, it can cause damage to brain connections or other damage, and autism directly relates to missing brain connections.



Weight Of Memory
Deinonychus
Deinonychus

Joined: 16 Jun 2023
Gender: Male
Posts: 317
Location: Florida

20 Oct 2023, 5:55 am

So people aren't necessarily born with autism after all?



Recidivist
Veteran
Veteran

User avatar

Joined: 4 Jan 2023
Gender: Male
Posts: 3,851
Location: He/him/his

20 Oct 2023, 6:14 am

Now worried that I gave my sister undiagnosed autism when I accidentally smashed her head into the ceiling :(


_________________
Another man's freedom fighter, one man's terrorist is - Yoda (probably)


blitzkrieg
Veteran
Veteran

Joined: 8 Jun 2011
Age: 115
Gender: Non-binary
Posts: 17,820
Location: The line in the sand

20 Oct 2023, 6:41 am

Mountain Goat wrote:
Regarding the thread title, it is an obvious statement because autism is caused by missing brain connections in the frontal part of the brain, where various hypersensitivities and also certain areas of genuis amongst a few are where during brain development (While the brain is growing), the brain often directs growth into other brain areas of it realises that certain areas are damaged. (Is actually wonderful how the human body does this during development).

Now fits are caused by brain connections shorting so they don't nowhere they are supposed to (Hence the uncontrolled movements). Fortunately the majority of fits are temporary but unfortunately can be fatal in extremes. Fits are not always associated with brain development as some people who may never ever have had a fit, can has a fit due to certain external or internal stresses of situations (E.g. Such as an incorrectly administered or an incorrectly dosed local anaesthetic while at the dentist, where some dentists are not even aware there is a certain measurement of else for a certain body mass size etc, which if too little is administered the patient can feel the pain, but if too much is administered it can lead to fits of cardiac arrest... (Why any had experiences should immediately be followed by a 24 your hospital observation period).

Then we have another brain issue which autism is often misdiagnosed as which is a chemical imbalance in the brain called "Bipolar" where sufferers to from highs to lows. Autism sufferers can also go from highs to lows hence the missdiagnoses. The common notable key difference between the two is that bipolar surferers to from a high to a low in a period of a typical four day cycle (E.g. A low eventually turns into a high four days later etc). Autism sufferers who go from highs to lows due to the brain function rather than a chemical imbalance can go from highs to lows in the same day of even in the same hour. With bipolar it takes a few days for the brain chemicals to change. The good news with bipolar is one can alter the brain chemistry through medication. The importance of correct diagnoses is understated because if autism is misdiagnosed as bipolar, and the patient receives medication, the medication (While the patient is receiving it) actually causes bipolar episodes on top of the natural autism trait, so their lives while on the incorrect medication can be absolutely horrible!

While the vast majority of cases of autism are caused in the development of the brain, it has also been known for those involved in more serious motor accidents to develop autism after the accident. This is due to the damage received to the frontal area of the brain.
(I don't know why autism specifically relates to the frontal area of the brain, but in all the things I have read, they specifically mention that it does. Makes one ask what the other areas of the brain do and what would happen if a patient had an issue with one of these other areas, what the symptoms may be? I have not read anything about this. Next time I visit where I used to live I can ask as a neighbour as she is a brain surgeon, so she might be able to tell me... Though her expertise is in a specific area which I think relates to emergency brain operations? When I was asking her about autism it wasn't her area of expertise though she was highly interested. I also got to talk to another lady who was using an ECM machine on me to check if I had fits. I learned a bit from her as she was able to tell.me what was and what was not possible to monitor in the brain, after I panicked as I thought they could read my thoughts! She was at the forefront of medical technology and she said that she doubted within her lifetime (She was in her 30's) that they would ever be able to do that as the brain has many millions more connections than even the largest computer has and is also a whole lot quicker).


But going back to the title. Yes. It is a given obvious statement as if the brain is inflamed during development, it can cause damage to brain connections or other damage, and autism directly relates to missing brain connections.


Missing brain connections isn't a scientific term.

I think what you are getting at there is "white matter abnormalities", whereby white matter that is threaded through grey matter throughout the brain, sometimes breaks down and can cause autistic pathology due to a lack of connectivity between different regions of the brain.



Weight Of Memory
Deinonychus
Deinonychus

Joined: 16 Jun 2023
Gender: Male
Posts: 317
Location: Florida

20 Oct 2023, 11:04 am

Recidivist wrote:
Now worried that I gave my sister undiagnosed autism when I accidentally smashed her head into the ceiling :(


That must have been a low ceiling?

I fell down two different flights of stairs as a child on two separate occasions. I only remember the second incident; nobody else witnessed it except the family dog. The first fall I only know because my mother mentioned a few times; I was presumably younger for that one. I also (apparently deliberately) headbutted her as an infant - hard enough that she would also mention it more than once.

I have a friend who has ADHD and OCD (maybe undiagnosed ASD), attributed to a severe fever she had as an infant.

Kids get hurt all sorts of ways.



IsabellaLinton
Veteran
Veteran

User avatar

Joined: 1 Nov 2017
Gender: Female
Posts: 72,422
Location: Chez Quis

20 Oct 2023, 11:37 am

Fnord wrote:

In their research, the team from the University of Maryland School of Medicine targeted a portion of the brain known as the cerebellum ....[/i]



I agree - I've been posting about the connections between cerebellar damage and autism since I first joined here. I've had two strokes in my cerebellum and read a lot about cerebellar function. It's a part of the brain that's responsible for nearly all the "skills" we struggle with in autism. I was born autistic according to my early development but my strokes in adulthood only made the autism worse, to the point I cannot mask or function the way I used to, which was never great in the first place. I'm seeing a Naturopath now to deal with whole-body inflammation so I'll ask her thoughts on this.


_________________
I never give you my number, I only give you my situation.
Beatles


blitzkrieg
Veteran
Veteran

Joined: 8 Jun 2011
Age: 115
Gender: Non-binary
Posts: 17,820
Location: The line in the sand

20 Oct 2023, 11:44 am

Even when brain inflammation leads to autism (in my opinion it does, it isn't just a speculation) - that doesn't mean all cases of autism are caused by that.

I have seen similar studies done solely for schizophrenia, where there was a correlation, perhaps with causation of schizophrenia being linked with air pollution levels (an inflammatory mechanism that occurs because of this results sometimes in schizophrenia).