Or, some variation thereof? E.g. "Are you a moron / ret*d / nincompoop", or "Were you dropped on your head as an infant?", or "Do you have some sort of mental problem?"
Now obviously, these questions are rhetorical - and not constructive and bridge-building at all.
They usually seem to come about from misinterpreting "what they REALLY meant" in responding to someone's verbally stated wishes to you. Or, not being able to predict how so-and-so might react to something you did that you thought, logically, made total sense.
Or, possibly when asking to clarify "obvious" expectations - asking one too many questions.
I think a clever retort to this sort of very insulting rhetorical question would be: "No, I just have high standards for things making sense. There's a fundamental difference."
Or "No, I just have an alternative thought process."
I remember on one occasion I got a more veiled version of this insult where somebody asked me with derision, "What do you do for a living?" I replied, truthfully, that I had a successful career in CS/IT, and the person replied "Oh, THAT explains a lot!!" again with a derisive scoff.
On another occasion, I got a more stinging insult of "I don't know how somebody like you manages to stay employed."
Which, I think sums up their aggressive and hateful responses like those at the top of this post: they just "thin-slice" us as being mentally incompetent not-all-there people who are burdens on society. They just conjure up some gut image / archetype of "our kind" even if they've never heard of ASD.
Of course, in some situations you may have to just endure the abusive remark like if it's a boss or someone high up in the org hierarchy... or if it's a customer and you're in a customer-facing job like retail or counter service or something. Well, then again, in this day and age there's ever more signage being posted that the company has "zero tolerance abuse policies" on verbal abuse of staff, and the aggressor will be asked to leave or police will be called. I haven't been in one of those jobs since my youth in the '90s, before my diagnosis, but it had its stressful moments
I can imagine that for my fellow Aspies, if they've found themselves in such a customer-facing post and having to deal with the rants of a Karen or a Kevin, they'd have to muster the courage to tell them to leave and you won't tolerate abuse. However, if the manager gets involved one too many times, they'd soon surmise that YOU are the cause of the abusive customer snapping and calling you names, and they'd probably sideline you to the back doing menial work. Or, they might just fire you
I really think that once any one of us gets an "Are you stupid?!?!" type of blow-up, it's the beginning of the end.