It annoys me. The common one I get is "hey how's it going?" It's a pointless thing to say. Most of the time I don't even respond, I just smile mechanically. Checkouts at supermarkets are classic for stupid, socially confirming pointless words. You get there and they say "hi how are you?" (Doesn't that drive them nuts 50,000 customers a day?) but they aren't actually asking for information, so the exchange is redundant. You pay the bill and they say "have a nice day" which is such an incredibly stupid thing to say I'm dying to get it printed on a t-shirt. I hate questions, and obviously I hate small talk. Pointless talking in general rubs my fur backwards.
My pet hate at the moment, though, is personal questions. I don't know if it's because of facebook, but people seem suddenly to think they have the right to ask you the most intrusive, personal questions that are none of their business. It seems the concept of privacy is foreign to modern consciousness. Just random people at work who I don't know from a bar of soap start asking me where I live, who I live with, why I wanted to be in the job, if I have a boyfriend, how long have I been with him, what I do in my spare time, when I'm planning to move house, etc etc etc. I hate being scrutinized like that and actually find the very asking offensive.