Autism Compared To Sickle Cell--Comments?

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Polgara
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09 Oct 2009, 11:55 pm

I have a theory about autism and Asperger's. Feel free to punch it full of holes! :D

I have read where sickle cell anemia comes about when a person has the gene from both parents. It's a serious, dangerous thing. A person who has only one copy of the gene, however, will have sickle cell trait. It is a lot less dangerous and may never show any symptoms. However, it provides a significant protection from malaria; people with the trait who contract malaria are much more likely to survive.

I have the feeling that classic extreme autism corresponds to the sickle cell disease, and Asperger's to the trait. I am not saying that it's an exact parallel, just that there seems to be some similarities in their relationship. Classic autism makes it much more difficult for a person to make a significant contribution to the species because communication is a major problem. However, I do believe that through the ages it has been the Aspies who have come up with a lot of the real advances in technology, and that without them we would probably all still be hunter-gatherers. Sort of as if it were like sickle-cell communication, or sickle-cell perception. I'm relating this to the differences autistics and aspies share compared to NTs. I really don't have any data to back this idea up, and I'm just too lazy to do the research to get some.

Responses?



racooneyes
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10 Oct 2009, 12:15 am

So just for clarity; in the comparison having both sickle-cell genes to being an aspie and one gene to being a classic autie and wether or not we contract malaria to our usefulness in society? That's quite complicated but I think I got ya :lol:

Um yeah, interesting if tenuous comparison. I'm not sure I agree with the part about no progress without aspies though but it could certainly be a factor.


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Polgara
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10 Oct 2009, 2:44 pm

I'm thinking less progress because although many NTs would be able to think of improvements to a spear or a plow, I think it's more likely that someone who perseverates on a task or problem and does not think like the other members of the tribe is more likely to be the one to think of a whole new tool, like a bow and arrow or a canoe built on a framework, rather than a dugout which is basically an improved log.



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10 Oct 2009, 4:36 pm

Hm. I think I read somewhere in large populations of "nerds" (or whatever the NT term is for people they don't know are aspie), they're finding that the children of those nerds are classically autistic.

So...

two aspies are having classically autistic children.

That's not always a given, but I was reading an article that said that silicon valley had an unusually high percentage of classically autistic kids. Considering how many people working there are probably aspie...

Interesting.



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10 Oct 2009, 4:41 pm

Perhaps it is more something like "broader autism phenotype - sickle cell trait; autism and asperger - sickle cell disease".



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10 Oct 2009, 5:05 pm

Polgara wrote:
I have a theory about autism and Asperger's. Feel free to punch it full of holes! :D

I have read where sickle cell anemia comes about when a person has the gene from both parents. It's a serious, dangerous thing. A person who has only one copy of the gene, however, will have sickle cell trait. It is a lot less dangerous and may never show any symptoms. However, it provides a significant protection from malaria; people with the trait who contract malaria are much more likely to survive.

I have the feeling that classic extreme autism corresponds to the sickle cell disease, and Asperger's to the trait. I am not saying that it's an exact parallel, just that there seems to be some similarities in their relationship. Classic autism makes it much more difficult for a person to make a significant contribution to the species because communication is a major problem. However, I do believe that through the ages it has been the Aspies who have come up with a lot of the real advances in technology, and that without them we would probably all still be hunter-gatherers. Sort of as if it were like sickle-cell communication, or sickle-cell perception. I'm relating this to the differences autistics and aspies share compared to NTs. I really don't have any data to back this idea up, and I'm just too lazy to do the research to get some.

Responses?


Sickle Cell Anemia is actually an survival adaptation in countries where insect carried diseases (such as malaria) are endemic. The heterozygous from of S.C.A. renders one immune (or more immune) to malaria even though it is somewhat debilitating. The Homozygous form is almost always fatal. On balance it is a survival characteristic which is why it has not been eliminated by natural selection.

Autism in any of its forms is not a fatal conditions (as such) although it makes life tough for those who have it and their care-givers.

ruveyn



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10 Oct 2009, 5:38 pm

There are some studies showing that "giftdness" and schiziophrenia run in the same families (some authors explain the persistence of schiziophrenia by this).

Perhaps there is a similar case for autism (specially attending that much probably the schizophrenia spectrum and the autism spectrum have genes in common - after all, the milder variants of both spectrums are basically indistinguishable)



Polgara
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10 Oct 2009, 5:42 pm

Quote:
Sickle Cell Anemia is actually an survival adaptation in countries where insect carried diseases (such as malaria) are endemic. The heterozygous from of S.C.A. renders one immune (or more immune) to malaria even though it is somewhat debilitating. The Homozygous form is almost always fatal. On balance it is a survival characteristic which is why it has not been eliminated by natural selection.
What I said, much better phrased.

Quote:
Autism in any of its forms is not a fatal conditions (as such) although it makes life tough for those who have it and their care-givers.


I was thinking more analogy than exact parallel. People with extreme forms of autism are a lot less likely to reproduce, and I imagine in years past had a worse survival rate for socioeconomic and cultural reasons. I understand that myths about "changelings" may have been based on perceived "wrongness" about young children and bad things have been known to happen to suspected changelings in the past. Or there were suspected demon possessions; imagine what a real meltdown would have looked like to some villager in the Middle Ages. Aspies, on the other hand, could have been anybody. Wonder how many hermits were Aspies. I know the idea has occurred to me from time to time! :lol: But think about the ancient Greeks and their inventors. Think about Mendel, who was a monk and developed the idea of genetics. Most people in any time sort of continue as it has "always" been done, and have to be dragged into the next new technology. Using horses, plows, the wheel, who knows? Who thought of a way to keep fire?



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10 Oct 2009, 10:24 pm

when i saw the title i thought you might actually be trying to suggest that there was a link between sickle-cell disease and AS/autism.
which is absolutely absurd, so originally i came in here to laugh at you :P .

but now i see that's not true.
though i don't concede to believe fully your theory nonetheless. though it is an interesting notion 8)


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11 Oct 2009, 3:24 pm

Polgara wrote:
[. Or there were suspected demon possessions; imagine what a real meltdown would have looked like to some villager in the Middle Ages?


Yes, it would look like demon possession. And stimming would look like casting a spell and echolalia would sound like witchy incantations. Sometimes my husband and I (a couple of nerds with a classical autist daughter- per your theory) would joke that it would start to rain when our daughter was stimming. It was her rain dance we would say. Then it occured to me that classic autists of the middle ages probably died for that. Brrrrrrr. We get to joke that stimming looks like a rain dance and echolalia sounds like a magical incantation and that's all just great in the 21st century. But back then it could get you burned at the stake and probably did to many people.