It could have something to do with visual ability, in this sence. Don't feel alone there, as my supposedly NT mother can get lost in a single room in computer gameing. She did it so often in Ever Quest, and still does this in World of Warcraft occasionaly. She's learned to get lost less often, because she's pretty used to it now.
Whatever game you play, some spots are dark, or they look the same distance despite you being far away or next to the wall, so you think your character is moveing when they are not. Then there is the shape of the rooms, buildings and such. Most of them look alike, and one has to first get used to that to the point that their brain learns another method of exploration when progressing stops suddenly. Alot of games are like mazes, even if getting lost wasn't the intent.
Some people pick out the very tiny differences sooner than others. Course some people think about details too much and get lost because of that. That's what my mother does. She thinks about parts that don't need to be thought on, and get's lost as a result. That doesn't just include play either. She gets lost for that reason alone, usualy, so I can see how some Aspies can have that problem. An Aspgergers person, certainly, will choose the logical reaction first, rather than sense of the place or motion, I think.