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kate123A
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17 Jun 2011, 9:32 am

From the sound of it, it's not a conclusive test for ASD's. They can find one of the genetic markers, yes, but their test shouldn't be in any way conclusive just from that. It's more of a "this child is at risk for ASD" than any kind of a proof.



ci
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17 Jun 2011, 11:41 am

If the test is possible there is little that can done about it. Some others have talked about violence toward the N.T concept. I think it is wise to emphasize non-violent social protests and to really keep the issue separate from other issues. It can be an emotional concept but people should remember that it's not them being potentially aborted.


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CockneyRebel
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17 Jun 2011, 11:54 am

I'm Pro-Life and I believe in the sanctity of life for all people from conception from conception until natural death and that includes people with autism.


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ci
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17 Jun 2011, 12:01 pm

The issue is best kept in the realm of pro-life and pro-choice politics. It taints other issues such as employment inclusion, asking for services and perceptions of society when asking for society to change or help. I am neither pro-life or pro-choice in the traditional senses. I follow the law for what the law states and I recommend others seek to modify the law if that is what they want. I am a man and not a women and no matter what the issue is complicated as I am not the one trying to make policy about my body.


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aghogday
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17 Jun 2011, 1:43 pm

kate123A wrote:


Quote:
The decision to focus on ASD stems from a compelling opportunity to help community physicians order genetic testing for children who are under their care. Currently, the genetic evaluation of children with ASD and developmental delay is delayed because most testing is ordered by specialists whose availability is limited. By providing this testing to the primary care pediatricians, genetic evaluation occurs earlier, possibly resulting in earlier therapeutic intervention for those children in need of support.


There is no indication from the link, that I can see that states a prenatal genetic test has been developed. This is a genetic test to provide a earlier diagnosis of chlidren with ASD's that have developmental delays. Early intervention in developmental delays, such as verbal communication is important in providing a child the opportunity to reach their full communicative potential. This is not a negative development, unless a person believes a child with developmental delays should go without the opportunity for support to be able to fulfill their potential.


from the article:

Quote:
Why is CMA testing important?


Recent publications in scientific and medical journals, including Pediatrics and The American Journal of Human Genetics, suggest that CMA should be offered as a first-tier genetic test for patients with unexplained DD/ID, ASD, or MCA.


A recent article written by Manning and Hudgins for the American College of Medical Genetics’ Professional Practice and Guidelines Committee, and published in the ACMG Practice Guidelines, states that “CMA testing for copy number variation (CNV) is recommended as a first-line test in the initial postnatal evaluation of individuals with the following: A) multiple anomalies not specific to a well-delineated genetic syndrome, B. Apparently non-syndromic developmental delay/intellectual disability, and C) autism spectrum disorders.”


You are the second person to post this information, stating it is a prenatal test. I don't think two people would have posted it unless they are reading something into it by mistake that is not there. My opinion is this may be what is confusing people:

Quote:
The FirstStepDx test comprises a comprehensive service that includes pre- and post-test genetic counseling and a detailed report delivered in an easy-to-read format, suitable for both physicians and families.


Pre- and post-test genetic counseling doesn't mean prenatal testing, it means genetic counseling before the genetic test is given and genetic counseling after the results from the test have been received.

I looked over the whole website. If there is anything there that indicates that this test is being used prenatally, please provide the quote that I am missing.



Last edited by aghogday on 17 Jun 2011, 2:13 pm, edited 1 time in total.

vermontsavant
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17 Jun 2011, 2:02 pm

did they say what gene its could be related to.for a long time people have suspected a link between autism and the fragile x chromisone or could it e trisomy related


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Oodain
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17 Jun 2011, 2:24 pm

untill we understand the process of non coding dna any real reliable prenatal test will be virtually impossible.


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aghogday
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17 Jun 2011, 3:13 pm

vermontsavant wrote:
did they say what gene its could be related to.for a long time people have suspected a link between autism and the fragile x chromisone or could it e trisomy related


There is an association between those conditions and many others; however the genetic markers for those conditions are not considered to be directly related to Autism.

There is a link on their site to all the available markers it tests on their website. This is it. There are about 15 genetic markers here for autism, but keep in mind that these markers are only correlated to Autism, in some instances 1 in a hundred cases of autism are associated with some of these markers.

One of biggest advantages of the test, is it may show markers in children of genetic conditions not directly related to Autism that are known to cause developmental delays in children with Autism, such as fragile X syndrome, thereby providing an earlier opportunity for beneficial interventions to allow the child to reach his/her potential.

http://www.lineagen.com/Our_Services___FirstStepDx___Markers_%26_Conditions___Sorted_by_Marker.html



John_Browning
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17 Jun 2011, 3:46 pm

While that link is disturbing, it sounds like they are embellishing their findings to attract new investors.


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aghogday
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17 Jun 2011, 4:49 pm

John_Browning wrote:
While that link is disturbing, it sounds like they are embellishing their findings to attract new investors.


Quote:
Changing the Diagnostic Odyssey of Autism


There is another level of assistance here in the potential for early intervention and Autism, but a GP would not likely order the test unless there were other factors that might lead to a possible diagnosis of Autism. Their statement here makes the test sound revolutionary, however a test for children for fragile X syndrome has been around for quite some time, and has already been suggested as a screening test for children with Autism. The other Autistic markers, for the most part, are not significant to know what kind of intervention might be required, until the behavior or lack of behavior is actually observed in the child.