The content is good, but regarding webdesign there could be improvements. I speak as a experienced amateur webmaster. At the index page should either a welcome or brief introduction. The purple font in the middle is well... hard to read... more suitable for headers. I have the view that every link should appear different when you roll the mouse over it. For instance the menu panel on the left, yes does that, but the quotes is not entirely obvious are links. Partially sighted people, or even someone with glaucoma (such as I) may not notice the cursor changing to the hand. Even a text link can be made to look like a link (underlined, different hover color). I could go on in much the same vein for a number of other features, but these are the main ones that would comment on on first impression.
Being a charity, it should be clear about its causes, and this should be spelt out briefly and clearly on the index page.