Interesting, I just looked up "trepanation" - I had heard of it before, but I didn't know it had a name. So, both trenpanation and giving Risperdal to children have been done ... but, unlike trenpanation, Risperdal can be helpful in extreme cases when there are no other options. It certainly wouldn't be my first choice if I had an extremely irritable autistic kid (the side effects!), but at least it does work.