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Roman
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19 Nov 2012, 6:01 am

Here is one thing worth reading: http://www.sntp.net/drugs/thorazine.htm



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21 Nov 2012, 1:23 pm

Roman wrote:
If you are saying that you hope that decrease of reuptake of serotonin (by means of prozac) would lead to accumulation of serotonin, that is more reasonable. But in this case, just administer serotonin directly


Reducing reuptake of serotonin will increase the amount available to neurotransmitters (think of it a bit like a sink, to increase the water level you can either increase the flow of water entering, or reduce the amount of water leaving).

Serotonin cannot cross the blood-brain barrier, it would need to be injected directly into the brain to have an effect (other body systems, such as digestion, use serotonin for signalling, so oral consumption would affect them, but not [directly] mood).



Roman
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21 Nov 2012, 3:06 pm

xmh wrote:
Roman wrote:
If you are saying that you hope that decrease of reuptake of serotonin (by means of prozac) would lead to accumulation of serotonin, that is more reasonable. But in this case, just administer serotonin directly


Reducing reuptake of serotonin will increase the amount available to neurotransmitters (think of it a bit like a sink, to increase the water level you can either increase the flow of water entering, or reduce the amount of water leaving).

Serotonin cannot cross the blood-brain barrier, it would need to be injected directly into the brain to have an effect (other body systems, such as digestion, use serotonin for signalling, so oral consumption would affect them, but not [directly] mood).


It is a bit surprising you said serotonin can't cross blood brain barrier. I mean prozac is structurally similar to serotonin (enough so to block the receptors). So since prozac clrearly crosses blood brain barrier, why can't serotonin do the same?



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21 Nov 2012, 3:21 pm

I don't have the knowledge of chemistry to explain what can cross the blood-brain barrier, however 5 HTP can cross the barrier, when serotonin (which is 5-HTP with a couple of molecular groups removed) cannot. (see italicised text for image).

Fluoxetine (Prosac)is significantly different to both, however part of its structure must be able to fit into the receptor sites and prevent reuptake of serotonin.



kotshka
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21 Nov 2012, 3:38 pm

I'm taking all bets at 1,000:1 against anyone participating in this thread changing their opinion/belief on this matter based on anything said in this thread.

Nothing like watching a group of people standing in a room wearing earplugs and screaming at each other... Naturally some of those people will be absolutely right and have their sources well-cited and arguments well-presented, but that doesn't make the earplugs any less effective. (They are very good earplugs.)

And with that, I will back slowly out of the room and try to escape quickly. Enjoy your argument guys!



madnak
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23 Nov 2012, 4:12 am

kotshka wrote:
I'm taking all bets at 1,000:1 against anyone participating in this thread changing their opinion/belief on this matter based on anything said in this thread.

Nothing like watching a group of people standing in a room wearing earplugs and screaming at each other... Naturally some of those people will be absolutely right and have their sources well-cited and arguments well-presented, but that doesn't make the earplugs any less effective. (They are very good earplugs.)

And with that, I will back slowly out of the room and try to escape quickly. Enjoy your argument guys!


I agree that participants in the thread are unlikely to be influenced, but lurkers/passive viewers may be another story. Regardless, I think the thread has largely run its course so I don't intend to write any more long posts.



aussiebloke
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09 Dec 2012, 7:35 pm

sunshower wrote:
And I thank the heavens for psychiatry every day as it effectively saved my life, without psychiatry I would have no quality of life.


Are you off the dsp now ?


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sunshower
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10 Dec 2012, 8:02 pm

aussiebloke wrote:
sunshower wrote:
And I thank the heavens for psychiatry every day as it effectively saved my life, without psychiatry I would have no quality of life.


Are you off the dsp now ?


No, still on it. Won't be able to go off it until I finish my studies.


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aussiebloke
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13 Dec 2012, 9:25 pm

sunshower wrote:
aussiebloke wrote:
sunshower wrote:
And I thank the heavens for psychiatry every day as it effectively saved my life, without psychiatry I would have no quality of life.


Are you off the dsp now ?


No, still on it. Won't be able to go off it until I finish my studies.


Well that's nice I was going to offer you some "advise" via PM since I'm an expert on it 11 years ! !! Try to make the best of a bad situation, according to my Swiss " family " sun myself up on the GC beaches. :roll:

What to do for employment now :? / :roll:


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mycats
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17 May 2014, 5:48 pm

Even though general traditional lobotomy is now outlawed, there should still be concern of if this is being done illegally. The psychiatric profession is either run by low IQ idiots or brilliantly evil psychotic demonically possessed people.

Hi IQ is a mental illness to them. If you have a high IQ and go into designing microprocessors used to run computers to spy on us, you are fine. If you have a high IQ and pursue the human rights of people who think differently and don't conform to the majority, then you are a threat. The government will find a way to commit you because to them high IQ is a severe mental illness. Crime continues to happen. There is still a threat of illegally performed lobotomy.



Raziel
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17 May 2014, 7:34 pm

Roman wrote:
madnak wrote:
The alternative to psychosurgery is often death.


1. In a lot of cases it is the psychiatrist that thinks the patient is a threat to themselves which is not true.

2. The cingulotomy aims at curing OCD, which is not life threatening.

3. If the patient is in fact a threat to themselves, physical restraint is far better option. At least physical restraint is reversible, while brain damage is not.


It's still something different...
but I can understand that quite well. If I wouldn't have gotten my surgery because I'm FtM-Transgender, I would have committed suicide. One doctor actually wanted me to stop, but no one who doesn't know how painful this can be should judge or try to stop others. To physical retrain people? Everyone has it's free will and I was never a fan from forcing others to live. If someone wants to kill themself they'll go ahead sooner or later. You can't stop them forever, it just doesn't work. So it's better to find a solution a person has at least a chance to live with and this surgery is just done as "ultima ratio", so this means there is no other alternative. You know in my situation the alternative would have been death, so what did I have to loose? And if someone would have forced me to continue to live without a surgery, my life would have been a living hell.

It's another surgery in my case I know, but still a surgery because of neuropsychiatric issues.


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