if you're talking about depression- a combo of regular vigorous outdoor physical exercise, omega 3 oils, regular sunlight exposure, cognitive hygiene, proper nutrition have all been proven to fight depression. sexual side effects are the bugaboos of many seretonin-boosting pmeds such as SSRIs [like prozac, paxil, zoloft] and SNRIs [like cymbalta and effexor], tricyclics [anafranil and norpramin among others] and MAOIs [like isocarboxazid (Marplan), phenelzine (Nardil) and tranylcypromine (Parnate)]. if you must have an SSRI/SNRI, luvox [SSRI] and pristiq [SNRI] have fewer sex side fx than their stablemates, but the antidepressants with the fewest sexual side fx are bupropion [welbutrin] and myrtazapine [remerol]. if you must sake a sex-dampening antidepressant, you can temper their sex-killing properties by taking one's daily dose only after having sex for the day, or combining the dose with the antidepressant buproprion [welbutrin] or the anti-anxiety drug buspirone [buspar], and/or taking a vasodilator such as viagra, levitra or cialis, as long as one is not on nitrates or large doses of l-argenine.