I experience mania sometimes, and it usually is preceeded or followed by being intensely depressed. I get unusually irritable when I experience mania, drink and smoke more, self harm and engage more in my disordered eating habits, have a much higher libido and do things due to it that I regret later, etc. When I become depressed before or after I feel exhausted, get really suicidal, and just feel the complete opposite.
I actually didn't have many issues with this until I started Strattera, but it gets worse when I change my dose or stop taking it, so I haven't stopped taking it yet. My doctor said people with mood disorders respond to SNRIs the way I do though, so I don't know if the medication caused the issue, or just exacerbated something that I didn't know I had a problem with before.