There are several comics I follower fairly regularly, several others I don't. There are some adult themes in most of these.
XKCD - If you don't know this one, you may need to be shot.
Questionable Content - Silly, but not much of a point to it.
El Goonish Shive - Chaotic and fun, indescribable beyond that.
The Wotch - Spin-off of EGS. On hiatus.
The Wotch Cheer - Spin-off or The Wotch. Also on hiatus. Much more anime-style that in the other two; appears less though-out.
Misfile - Anime-style bugs me a bit, as does the lack of color, but can still be interesting.
Wapsi Square - Another magic-based comic, but about post-grad women. Exceedingly vague of late.
Supernormal Step - In some ways reminds me of Hitchhiker's Guide. About a girl who is pursued by the government and the anti-government group of an alternate universe she is trapped in against her will.
_________________
When I allow it to be
There's no control over me
I have my fears
But they do not have me