In my case, I've never been the recipient of any outright mean comments from women. I've been rejected countless times, but always with kindness.
But the toughest thing I heard, was recently when on a sorta date with a might-be-more-than-a-friend, we started getting candid about mental illness in our families, and in response I talked about autism in my family and how I was mildly autistic myself.
She nodded and said she had noticed things about me that were different and a little "off."
Again, she was very kind, and I know she meant no harm. But it was hard for me, because it finally confirmed a great fear and insecurity of mine, that no matter how hard I try to pass for normal in a public setting, no matter how hard I try to make myself into a more outgoing, charming, charismatic person, the sort of person a woman WOULD want, it will do no good because my Aspie-ness will always find a way to sneak out in ways I can control or even perceive. So it revealed to me that there wasn't much hope of me trying to remake myself or conform in the hopes of finding someone.
And with that illusion shattered, I've been trying to move on to a different place in my life....I'm giving up on dating or finding anyone, and focusing now on my work, on finding lasting meaning through it, and accomplishing something great to give to the world. And just learning to love being alone. Because I just probably won't ever find someone who'll accept or tolerate damaged goods like me.