I'm guessing nearly every guy with Aspergers here has looked at some hot chick that goes to their class and thought, "Man, I wish I could get to know her." Let's face it, we have some of the most trouble initiating conversation with the ladies. However, I've recently found somewhat of a formula that works everytime. It's as simple as this.
1. Try to get a seat next to her. If they're full, you can always talk to her after class.
2. Start by asking her how school has been. She will not automatically suspect you have a big crush on her just because you've never talked to her before as I foolishly assumed for so long.
3. Ask questions that relate to school (assignments, grades, other classes, etc.)
4. Make sure you get her name before you split. Repeating her name out loud helps to remember. If you forget it, don't be shy to ask her next time.
5. Next time you see her, ask how she's been, and if she's done anything since you last saw her. If she mentions seeing a movie, start talking about movies. If she mentions a family member, ask about her family. Ask about anything she mentions that could make for an interesting conversation. If she has nothing interesting to say for the time being, you can always ask another day. There's nothing abnormal about a conversation lasting only two sentences.
6. It is best not to talk about yourself until asked. She is very likely to ask you how you've been, so before you talk to her, you can prepare for this question by trying to remember anything that happened recently that could possibly start an interesting conversation. If eating a sandwhich was about the most interesting thing that happened all week, just say "fine," or "nothing much," depending on the question. You'll always have plenty of chances to talk to her later.
7. The most important thing is practice. These methods take a time to get used to, and they are by no means perfect. I'm sure many of you could do a lot to improve on my methods, but that's what the art of conversation is all about. You start simple, and slowly get better. You will make social no-no's along the way, but people will be quick to blow them off. Just be persistant, confident, and you will slowly transform from that sorry loser in the corner to a first-class ladies man.