Your original post was too vague, but your follow up post seems to indicate you are looking for tips on small talk, so here goes.
- Current events both in the news, and around the office.
- Latest disaster in the news. Lots of people talk about those.
- Sports
- Compliment someone on hair, clothes, work, etc.
- Ask about their families and kids, but only if you want a long spiel. And remember, if they are having family troubles, this could turn into an emotional dumping session, with you on the receiving end.
- Talk about travel to places they have been to, or may be planning on visiting.
- Cooking and recipes, if you like such things.
- Music, but remember we don't all like the same kinds.
- TV/movies/plays
- Books
- College/university/vocational school/online courses, if you/ they are taking any courses.
- Gardening, if you are into that.
- Car talk--mostly with guys.
Here are several topics to avoid, if at all possible, as they generate too much heat.
- Politics
- Religion
- Health--do you really want to know all the grisly details about their operation? If they bring up a health problem, just say you are sorry they haven't been feeling well, and hope they get better, soon. That last part should be left out if it's a terminal disease.
- Environment--Everyone is for the environment, but not we don't all agree on the problems and solutions, and this can become a heated discussion.
- Family, if the person is the sort to carry on about their family problems.
I'm sure I left some stuff out, but I put down all I could think of. 
_________________
If a man does not keep pace with his companions, perhaps it is because he hears a different drummer.
Let him step to the music which he hears, however measured, or far away.--Henry David Thoreau