I think I know what you are getting at muslimmetalhead. By the way, cool nickname, kinda paradoxical there if you go by the cultural cliches associated with a (conservative) muslim.
You do want an answer to a very general question, and I think your best answer is that you have to go by the context of the situation. Each situation may require a different interpretation and different response. Socializing, people may make it sound easy, but it can actually be hard for even NTs in situations too. You can generalize simpler things possibly such as if a person only answers you with one word answers constantly or keeps trying to walk away from you, then you have probably angered them, but of course not necessarily. Maybe they are tired, maybe they don't know how to respond properly, maybe they do not like your company, maybe an emergency came up and they don't want to talk about it, etc.