Well, it should be okay, since you are one of the hosts. Usually, the host will be managing taking care of guests part of the time. The rest of the time, it is considered polite for you to say hello to each person individually if you can. If it is a traditional party, the guests are supposed to make an effort to come say hello to you and chat for a moment, or at least say goodbye before they leave.
It doesn't have to suck just because you don't know the guests very well. It will be mentally tiring because it's a lot of new people, but some of them might turn out to be nice. Ask your husband to help you out to get to know them better.