I used to like it when I played the Sims.
In the Sims 1 I loved to put family members in a fence until they died of hunger. Because their mood went to red, they were more likely to be bad-tempered so I had a lot of fun getting their relationships to -100 as well.
I don't know if that's possible in the Sims 2 but since they have more feelings in the Sims 2, I usually like to kill one person and have the others greiving for days. One of my families had two parents, and a grown up son with his wife. I only liked the mother in there so I kept her young with youth elixirs... I also made the daughter-in-law fall in love with the father. Then I moved the father out and kept playing with him until he died... and thus, I made three Sims depressed at the same time.