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A Bone-Chilling Discovery Has Emerged From the Ice Age...

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skibum
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05 Feb 2024, 3:56 pm

I also agree that the use of the term bone chilling is also ridiculous click bait.


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cyberdad
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05 Feb 2024, 4:07 pm

Wait, African people have no Neanderthal or Denisovan DNA but autism is still prevalent in Africa??



funeralxempire
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05 Feb 2024, 8:24 pm

skibum wrote:
funeralxempire wrote:
skibum wrote:
This is actually good news for me. I am trying to prove that Autistic people are the original design.


How would a mutation absorbed from a non-Sapiens member of the genus Homo offer any insight into what's "the original design" for H. sapiens?

The earliest H. sapiens wouldn't have possessed any admixture from non-African members of Homo, therefore non-African members of Homo can offer zero insight into the original state of H. sapiens.

If a trait is possessed by Denisovians but not by Neanderthals nor by H. sapiens without Denisovian admixture that strongly indicates that trait is derived (new), not basal (original).

Beyond that, social skills are important survival skills for apes in general, not just H. sapiens who live over a certain density. Hunter/gatherers depend on social skills, those skills didn't only become important once agriculture emerged (at least based on any hunter/gatherer society that's been observed).
Any information at all about anything gives me insight


It gives you insight, yes.

It just doesn't support your hypothesis:

skibum wrote:
I am trying to prove that Autistic people are the original design.


The available data precludes your hypothesis so proving it isn't going to be possible.


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funeralxempire
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05 Feb 2024, 8:50 pm

cyberdad wrote:
Wait, African people have no Neanderthal or Denisovan DNA but autism is still prevalent in Africa??


Some Africans have some Neanderthal ancestry, but it's attributed to H. sapiens with Neanderthal ancestry migrating back into African, rather than direct interactions.

I haven't come across anything confirming Denisovian ancestry in Africans, the assumption appears to be that there is none.

https://www.newscientist.com/article/22 ... re-anyway/

https://www.cell.com/ajhg/fulltext/S0002-9297(19)30426-4
https://phys.org/news/2016-03-world-nea ... odern.html
https://academic.oup.com/gbe/article/15 ... ogin=false

According to another article African and East Asian populations have undergone different selective pressures on SLC30A9.

Quote:
Intriguingly, we found that SLC30A9 was underlying natural selection in both East Asians (EAS) and Africans (AFR) but in different directions. Notably, a non-synonymous variant (rs1047626) in SLC30A9 is almost fixed with 96.4% A in EAS and 92% G in AFR, respectively. Consequently, there are two different functional haplotypes exhibiting dominant abundance in AFR and EAS, respectively.


https://www.nature.com/articles/srep09658

That doesn't get into the origins of the variations, but does seem to state pretty strongly that they're not usually carrying the same SLC30A9.

This article also suggests it's not a cold adaptation but instead an adaptation driven by differing amounts of zinc available for absorption from local foods.

Regardless of the selection mechanism, if some populations produce autistic people but lack the Denisovian SLC30A9 variant, we can preclude SLC30A9 variability as a primary cause of autism.

Further, if the zinc transfer gene is a significant contributor, (my completely uneducated guess is that) we can probably offset the problems it does cause with zinc supplements.


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Cornflake
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06 Feb 2024, 6:26 pm

 ! Cornflake wrote:
Disagreements are fine, but being abusive to those who disagree is not.
Consequently a series of posts has been removed.

Please - if a disagreement is causing upset just ignore it and instead, address the agreements.


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cyberdad
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06 Feb 2024, 7:44 pm

Strange
https://www.cdc.gov/ncbddd/autism/addm- ... ences.html

autism is far higher in black children > all other groups
black children are also likely to have neanderthal DNA < other groups



naturalplastic
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07 Feb 2024, 11:10 am

cyberdad wrote:
Strange
https://www.cdc.gov/ncbddd/autism/addm- ... ences.html

autism is far higher in black children > all other groups
black children are also likely to have neanderthal DNA < other groups

Only now are they getting good data on minorities with autism.

But yes...folks from subsaharan Africa have little to no Neanderthal (nor Denisovian) DNA, and yet they have at least as much autism as anyone else.

Ergo Neanderthal DNA probably doesnt have much to do with autism. If anything.

Though Neanderthal and Denisovian DNA does effect folks other ways, good and bad.



cyberdad
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07 Feb 2024, 3:09 pm

naturalplastic wrote:
Only now are they getting good data on minorities with autism. .


There are some massive global DNA projects and gene databanks on autism, ID and ADHD collected now from millions of people both diagnosed with these conditions but also there immediate family and relatives. I am a little surprised that there isn't any strong statistical models developed yet in relation to hereditary patterns?