14 Aug 2009, 5:30 am
14 Aug 2009, 5:50 am
Other, I was on it but I had to put gluten back into my diet because my GP wants me to be tested for celiac. I've noticed differences in energy levels, distractability has gone up, stomach problems have returned, my moods have been worse too 
CockneyRebel
Veteran
Joined: 17 Jul 2004
Age: 50
Gender: Male
Posts: 116,919
Location: In my little Olympic World of peace and love
14 Aug 2009, 6:32 am
14 Aug 2009, 9:37 am
14 Aug 2009, 10:35 am
Reasons why people on the spectrum may be more likely than most people to find a gluten-free diet useful:
A very large, recent, study by Eaton et al, showed that children of mothers with celiac disease are three times more likely to be autist than children of mothers without an auto-immune disease, which suggests that gluten-intolerance, or sensitivity, may be more common among autists, indicating that a gf diet is more likely to be useful for someone on the spectrum than in the population at large.
And there are several studies which show that autists have higher levels of gliadin ( the offending bit of gluten ), and other anti-bodies, ( to various dietary proteins aswell as bacterial endotoxins/lipopoylysaccharides ), than the general population. A couple by Vojdani but here is another:
Quote:
Higher Plasma Concentration of Food-Specific Antibodies in Persons With Autistic Disorder in Comparison to Their Siblings
Vladimir Trajkovski Aleksandar Petlichkovski et al. Institute of Immunobiology and Human Genetics, Faculty of Medicine, University Ss. Kiril and Metodij, Skopje
Specific IgA, IgG, and IgE antibodies to food antigens in 35 participants with autistic disorder and 21 of their siblings in the Republic of Macedonia were examined. Statistically significant higher plasma concentration of IgA antibodies against alpha-lactalbumin, beta-lactoglobulin, casein, and gliadin were found in the children with autistic disorder.
Plasma concentrations of IgG antibodies against alpha-lactalbumin, beta-lactoglobulin, and casein in participants with autistic disorder were significantly higher. IgE-specific antibodies (alpha-lactalbumin, beta-lactoglobulin, casein, and gluten), as well as plasma concentration of total IgE, also were statistically significantly higher in the participants with autistic disorder. Gender differences were found for select IgA, IgG, and IgE (but not for total IgE) food-specific antibodies (kU/L) in the participants with autistic disorder and their siblings.
.
Vladimir Trajkovski Aleksandar Petlichkovski et al. Institute of Immunobiology and Human Genetics, Faculty of Medicine, University Ss. Kiril and Metodij, Skopje
Specific IgA, IgG, and IgE antibodies to food antigens in 35 participants with autistic disorder and 21 of their siblings in the Republic of Macedonia were examined. Statistically significant higher plasma concentration of IgA antibodies against alpha-lactalbumin, beta-lactoglobulin, casein, and gliadin were found in the children with autistic disorder.
Plasma concentrations of IgG antibodies against alpha-lactalbumin, beta-lactoglobulin, and casein in participants with autistic disorder were significantly higher. IgE-specific antibodies (alpha-lactalbumin, beta-lactoglobulin, casein, and gluten), as well as plasma concentration of total IgE, also were statistically significantly higher in the participants with autistic disorder. Gender differences were found for select IgA, IgG, and IgE (but not for total IgE) food-specific antibodies (kU/L) in the participants with autistic disorder and their siblings.
.
And here is part of a paper by Vojdani on prevalence and symptoms of gluten sensitivity:
Quote:
The immunology of gluten sensitivity beyond the intestinal tract
Aristo Vojdani, Ph.D., M.T.1*; Thomas O’Bryan, D.C., C.C.N., D.A.C.B.N.2
Gluten sensitivity, celiac disease (CD) and gluten-sensitive enteropathy are terms that have been used synonymously to refer to a disease process affecting the small bowel and characterized by gastrointestinal symptoms and malabsorption. However, since 1966 scientific evidence has been accumulated demonstrating that gluten sensitivity can exist even in the absence of enteropathy. For example, patients with dermatitis herpetiformis and presentation of blistering skin do not have any gastrointestinal symptoms but have elevated gliadin antibody in the blood which improves on a gluten-free diet.
Additionally, associations of CD with other organs such as the central and peripheral nervous systems also go as far back as 1966. However, until recently, this phenomenon of immune reaction against neural tissue, in particular the cerebellum, was attributed to vitamin deficiencies and not to immunological pathogenesis. During the past five years, based on overwhelming evidence of immune pathogenesis involving organs other than gut and skin, many scientists have begun to re-evaluate the notion that gluten sensitivity is solely a disease of the gut.
Other organs suspected of involvement include: the joint, the heart, thyroid, bone, the brain cerebellum and the neuronal synapsins which are summarized below.
Although it is believed that the prevalence of CD is one in one hundred, for every symptomatic patient with CD there are eight patients with CD with no GI symptom. In addition 10% of the apparently healthy population have significant elevation in gliadin antibody but no obvious classic disease manifestations. In our laboratory, when the blood of these individuals is tested against different tissue antigens (joint, myosin, endothelial cell, bone antigens, myelin basic protein, cerebellar and synapsin peptides) more than 90% of them exhibit elevation in IgG, IgM and IgA antibodies against one or all these organ-specific antigens.
.
Aristo Vojdani, Ph.D., M.T.1*; Thomas O’Bryan, D.C., C.C.N., D.A.C.B.N.2
Gluten sensitivity, celiac disease (CD) and gluten-sensitive enteropathy are terms that have been used synonymously to refer to a disease process affecting the small bowel and characterized by gastrointestinal symptoms and malabsorption. However, since 1966 scientific evidence has been accumulated demonstrating that gluten sensitivity can exist even in the absence of enteropathy. For example, patients with dermatitis herpetiformis and presentation of blistering skin do not have any gastrointestinal symptoms but have elevated gliadin antibody in the blood which improves on a gluten-free diet.
Additionally, associations of CD with other organs such as the central and peripheral nervous systems also go as far back as 1966. However, until recently, this phenomenon of immune reaction against neural tissue, in particular the cerebellum, was attributed to vitamin deficiencies and not to immunological pathogenesis. During the past five years, based on overwhelming evidence of immune pathogenesis involving organs other than gut and skin, many scientists have begun to re-evaluate the notion that gluten sensitivity is solely a disease of the gut.
Other organs suspected of involvement include: the joint, the heart, thyroid, bone, the brain cerebellum and the neuronal synapsins which are summarized below.
Although it is believed that the prevalence of CD is one in one hundred, for every symptomatic patient with CD there are eight patients with CD with no GI symptom. In addition 10% of the apparently healthy population have significant elevation in gliadin antibody but no obvious classic disease manifestations. In our laboratory, when the blood of these individuals is tested against different tissue antigens (joint, myosin, endothelial cell, bone antigens, myelin basic protein, cerebellar and synapsin peptides) more than 90% of them exhibit elevation in IgG, IgM and IgA antibodies against one or all these organ-specific antigens.
.
If you hadn't already guessed, I am on a gf diet. And it makes a huge difference to my mental health; it has eliminated depression, hypomania, headaches, frequent infections, aswell as sleep problems, and brain-fog/confusion. In fact it has made so much difference to me, and I have read so much about it, and other links between diet and mental health, that I am making a presentation on the subject, ( connections between diet and mental health ), at Autscape in London next week!
.
14 Aug 2009, 11:06 am
14 Aug 2009, 11:33 am
14 Aug 2009, 11:52 am
14 Aug 2009, 12:06 pm
14 Aug 2009, 12:53 pm
14 Aug 2009, 2:17 pm
14 Aug 2009, 2:20 pm
14 Aug 2009, 2:26 pm
14 Aug 2009, 4:21 pm
15 Aug 2009, 8:40 am
*Quick back story on us - I am the mother of an almost 4 year old girl, Kaelyn, who has Autism. I am NOT trying to "cure" my daughter. I am working on finding NATURAL treatments that help her*
*sorry to qoute such a HUGE comment*
This is truly the most informative quote presented along side gf/cf that I have ever seen and in reading it, I see the reasons behind progress my daughter has made. We removed gluten in March of 08 and the results were drastic. We removed casein in December and the results were not nearly as remarkable, but physically, she did improve (firmer stools, her distended belly went down SOME, the dark circles under her eyes cleared up...) For us, it was the gluten removal that did wonders.
I have SEVERE digestive disorders myself, am finally seeing specialists for it and having my gallbladder removed. I will not be even faintly surprised if I find out I have Celiacs, though my PCP has yet to test me for it. I am banking on the specialist actually TRYING to help me.
As for my daughter, I cannot deny the gains she made on the gf diet. I am her harshest critic. A POSSIBLE gain is not a gain to me. It must be concrete.
Could you possibly link me to where you got all of these studies? I would love to do more research on it. I am an information junkie, especially in Autism.
ouinon wrote:
Reasons why people on the spectrum may be more likely than most people to find a gluten-free diet useful:
A very large, recent, study by Eaton et al, showed that children of mothers with celiac disease are three times more likely to be autist than children of mothers without an auto-immune disease, which suggests that gluten-intolerance, or sensitivity, may be more common among autists, indicating that a gf diet is more likely to be useful for someone on the spectrum than in the population at large.
And there are several studies which show that autists have higher levels of gliadin ( the offending bit of gluten ), and other anti-bodies, ( to various dietary proteins aswell as bacterial endotoxins/lipopoylysaccharides ), than the general population. A couple by Vojdani but here is another:
And here is part of a paper by Vojdani on prevalence and symptoms of gluten sensitivity:
If you hadn't already guessed, I am on a gf diet. And it makes a huge difference to my mental health; it has eliminated depression, hypomania, headaches, frequent infections, aswell as sleep problems, and brain-fog/confusion. In fact it has made so much difference to me, and I have read so much about it, and other links between diet and mental health, that I am making a presentation on the subject, ( connections between diet and mental health ), at Autscape in London next week!
.
A very large, recent, study by Eaton et al, showed that children of mothers with celiac disease are three times more likely to be autist than children of mothers without an auto-immune disease, which suggests that gluten-intolerance, or sensitivity, may be more common among autists, indicating that a gf diet is more likely to be useful for someone on the spectrum than in the population at large.
And there are several studies which show that autists have higher levels of gliadin ( the offending bit of gluten ), and other anti-bodies, ( to various dietary proteins aswell as bacterial endotoxins/lipopoylysaccharides ), than the general population. A couple by Vojdani but here is another:
Quote:
Higher Plasma Concentration of Food-Specific Antibodies in Persons With Autistic Disorder in Comparison to Their Siblings
Vladimir Trajkovski Aleksandar Petlichkovski et al. Institute of Immunobiology and Human Genetics, Faculty of Medicine, University Ss. Kiril and Metodij, Skopje
Specific IgA, IgG, and IgE antibodies to food antigens in 35 participants with autistic disorder and 21 of their siblings in the Republic of Macedonia were examined. Statistically significant higher plasma concentration of IgA antibodies against alpha-lactalbumin, beta-lactoglobulin, casein, and gliadin were found in the children with autistic disorder.
Plasma concentrations of IgG antibodies against alpha-lactalbumin, beta-lactoglobulin, and casein in participants with autistic disorder were significantly higher. IgE-specific antibodies (alpha-lactalbumin, beta-lactoglobulin, casein, and gluten), as well as plasma concentration of total IgE, also were statistically significantly higher in the participants with autistic disorder. Gender differences were found for select IgA, IgG, and IgE (but not for total IgE) food-specific antibodies (kU/L) in the participants with autistic disorder and their siblings.
.
Vladimir Trajkovski Aleksandar Petlichkovski et al. Institute of Immunobiology and Human Genetics, Faculty of Medicine, University Ss. Kiril and Metodij, Skopje
Specific IgA, IgG, and IgE antibodies to food antigens in 35 participants with autistic disorder and 21 of their siblings in the Republic of Macedonia were examined. Statistically significant higher plasma concentration of IgA antibodies against alpha-lactalbumin, beta-lactoglobulin, casein, and gliadin were found in the children with autistic disorder.
Plasma concentrations of IgG antibodies against alpha-lactalbumin, beta-lactoglobulin, and casein in participants with autistic disorder were significantly higher. IgE-specific antibodies (alpha-lactalbumin, beta-lactoglobulin, casein, and gluten), as well as plasma concentration of total IgE, also were statistically significantly higher in the participants with autistic disorder. Gender differences were found for select IgA, IgG, and IgE (but not for total IgE) food-specific antibodies (kU/L) in the participants with autistic disorder and their siblings.
.
And here is part of a paper by Vojdani on prevalence and symptoms of gluten sensitivity:
Quote:
The immunology of gluten sensitivity beyond the intestinal tract
Aristo Vojdani, Ph.D., M.T.1*; Thomas O’Bryan, D.C., C.C.N., D.A.C.B.N.2
Gluten sensitivity, celiac disease (CD) and gluten-sensitive enteropathy are terms that have been used synonymously to refer to a disease process affecting the small bowel and characterized by gastrointestinal symptoms and malabsorption. However, since 1966 scientific evidence has been accumulated demonstrating that gluten sensitivity can exist even in the absence of enteropathy. For example, patients with dermatitis herpetiformis and presentation of blistering skin do not have any gastrointestinal symptoms but have elevated gliadin antibody in the blood which improves on a gluten-free diet.
Additionally, associations of CD with other organs such as the central and peripheral nervous systems also go as far back as 1966. However, until recently, this phenomenon of immune reaction against neural tissue, in particular the cerebellum, was attributed to vitamin deficiencies and not to immunological pathogenesis. During the past five years, based on overwhelming evidence of immune pathogenesis involving organs other than gut and skin, many scientists have begun to re-evaluate the notion that gluten sensitivity is solely a disease of the gut.
Other organs suspected of involvement include: the joint, the heart, thyroid, bone, the brain cerebellum and the neuronal synapsins which are summarized below.
Although it is believed that the prevalence of CD is one in one hundred, for every symptomatic patient with CD there are eight patients with CD with no GI symptom. In addition 10% of the apparently healthy population have significant elevation in gliadin antibody but no obvious classic disease manifestations. In our laboratory, when the blood of these individuals is tested against different tissue antigens (joint, myosin, endothelial cell, bone antigens, myelin basic protein, cerebellar and synapsin peptides) more than 90% of them exhibit elevation in IgG, IgM and IgA antibodies against one or all these organ-specific antigens.
.
Aristo Vojdani, Ph.D., M.T.1*; Thomas O’Bryan, D.C., C.C.N., D.A.C.B.N.2
Gluten sensitivity, celiac disease (CD) and gluten-sensitive enteropathy are terms that have been used synonymously to refer to a disease process affecting the small bowel and characterized by gastrointestinal symptoms and malabsorption. However, since 1966 scientific evidence has been accumulated demonstrating that gluten sensitivity can exist even in the absence of enteropathy. For example, patients with dermatitis herpetiformis and presentation of blistering skin do not have any gastrointestinal symptoms but have elevated gliadin antibody in the blood which improves on a gluten-free diet.
Additionally, associations of CD with other organs such as the central and peripheral nervous systems also go as far back as 1966. However, until recently, this phenomenon of immune reaction against neural tissue, in particular the cerebellum, was attributed to vitamin deficiencies and not to immunological pathogenesis. During the past five years, based on overwhelming evidence of immune pathogenesis involving organs other than gut and skin, many scientists have begun to re-evaluate the notion that gluten sensitivity is solely a disease of the gut.
Other organs suspected of involvement include: the joint, the heart, thyroid, bone, the brain cerebellum and the neuronal synapsins which are summarized below.
Although it is believed that the prevalence of CD is one in one hundred, for every symptomatic patient with CD there are eight patients with CD with no GI symptom. In addition 10% of the apparently healthy population have significant elevation in gliadin antibody but no obvious classic disease manifestations. In our laboratory, when the blood of these individuals is tested against different tissue antigens (joint, myosin, endothelial cell, bone antigens, myelin basic protein, cerebellar and synapsin peptides) more than 90% of them exhibit elevation in IgG, IgM and IgA antibodies against one or all these organ-specific antigens.
.
If you hadn't already guessed, I am on a gf diet. And it makes a huge difference to my mental health; it has eliminated depression, hypomania, headaches, frequent infections, aswell as sleep problems, and brain-fog/confusion. In fact it has made so much difference to me, and I have read so much about it, and other links between diet and mental health, that I am making a presentation on the subject, ( connections between diet and mental health ), at Autscape in London next week!
.
15 Aug 2009, 9:59 am
KaeLainne wrote:
Could you possibly link me to where you got all of these studies? I would love to do more research on it. I am an information junkie, especially in Autism.
A few links and refs!
A. CELIAC DISEASE/ GLUTEN SENSITIVITY:
1 ) Celiac.com at http://www.celiac.com/ … particular pages of interest:
http://www.celiac.com/categories/Celiac ... -Disorders
http://www.celiac.com/articles/21669/1/ ... Page1.html
2 ) Huge collection of articles, research and links at “The Gluten File”:
http://jccglutenfree.googlepages.com/ and also on the brilliant info-packed forum connected to it
"Gluten Free and Beyond" at: http://glutenfreeandbeyond.org/forums/index.php3 ) Harold Kraus, at: http://members.cox.net/hal.kraus/gluten.htm
http://members.cox.net/hal.kraus/gluten/thebasics.htm ( about gliadins etc )
4 ) Other sites/articles about celiac disease/gluten intolerance, gf-diets, etc:
a. “Dyslexic Children Show Astonishing Improvements on Gluten-Free Diet”, at:
http://www.timesonline.co.uk/tol/news/u ... 444290.ece
b. “Sporadic Cerebellar Ataxia Associated with Gluten Sensitivity”
http://www.ncbi.nlm.nih.gov/pubmed/18825674 M. Hadjivassilou, and
http://brain.oxfordjournals.org/cgi/con ... 124/5/1013
c. “The Celiac Disease of Mental Illness”, Dr. Kaslow at:
http://www.drkaslow.com/html/gluten-brain_connection .html
B. FOOD INTOLERANCE/SENSITIVITY:
1 ) Food Can Make You Ill at: http://www.foodcanmakeyouill.co.uk/
And http://www.foodcanmakeyouill.co.uk/libr ... ories.html
2 ) The “Specific Carbohydrate Diet”
Chapter from Elaine Gottschall’s book “ Breaking the Vicious Cycle” at:
http://www.pecanbread.com/new/btvc1.html ( on autism and the Specific Carbohydrate Diet )
C. THE AUTISM ANGLE:
1 ) “Gene Could Link Autism with Digestive Problems” ( about the M.E.T. gene ) at:
http://www.sciencenews.org/view/generic ... bellyaches
http://pediatrics.aappublications.org/c ... 123/3/1018
2 ) Link Between Autism and Mothers with Auto-immune Diseases, ( especially celiac ):
http://www.celiac.com/articles/21857/1/ ... Page1.html
3 ) Immune Dysfunction, ( eg. cytokine reaction to certain proteins, etc ) and autism.
Overview at: http://autism.suite101.com/article.cfm/ ... d_immunity
4 ) Immune system hyper-reactivity/inflammatory responses and cytokine production triggered by common dietary proteins, bacterial endotoxins, etc in patients with ASDs. Jyonouchi H. and others; this is just one of the growing number of papers on the subject:
http://www.ncbi.nlm.nih.gov/sites/entre ... h=12378124
5 ) “Immune Response to Dietary Proteins, Gliadin and Cerebellar Peptides in Children With
Autism” by Vodjani A etc, at: http://www.ncbi.nlm.nih.gov/pubmed/15526989
6 ) “Higher Plasma Concentrations of Food Specific Antibodies in Persons with Autism”:
http://foa.sagepub.com/cgi/content/abst ... /176?rss=1
7 ) “Autism; a Brain Disorder, or a Disorder Affecting the Brain”, by Martha Herbert at:
http://www.marthaherbert.com/Herbert_CN ... _final.pdf
8 ) “Increased Oxidative Stress and Impaired Methylation Capacity in Children with Autism”
http://www.ajcn.org/cgi/content/abstract/80/6/1611 ( Jill James, Paul Cutler, et al. 2004 )
9 ) Impaired sulphation pathways in autists, and effect on amylase production, etc, at:
http://www.autismfile.com/papers/Rosema ... hation.asp
( ignore the brief Wakefield ref; she wrote the article before he was exposed, and her analysis does not depend on his results )
D. THE IMPACT OF PHYSICAL HEALTH ON MENTAL HEALTH:
1 ) “A Mind Under Siege” by Phyllida Brown at:
http://biopsychiatry.com/immunesystem/index.html
There are links to several brilliant papers about the impact of immune-system activity on mental health at the bottom of the page.
2 ) “Effect of Immune-system Activity on Mood and Memory” at:
http://mentalhealth.about.com/library/w ... 52101a.htm
3 ) “Activation of the Inflammatory Response System in Autism”. Products of the IRS may induce social withdrawal, resistance to novelty, and sleep disturbances:
http://www.websciences.org/cftemplate/N ... D=20005614
And this paper, ( below ), which I only found two days ago, and had me jumping up and down with excitement,
published in the Journal of Lipid Metabolism 2005, ( and cited in 56 papers so far ) suggests that a high-carbohydrate diet may be responsible for serious and widespread deregulation of lipid metabolism, which is known to be associated with a variety of neurological disorders and neuropsychological conditions, ranging from schizophrenia, bipolar disorder, through depression, alzheimers, cognitive impairment in the areas of attention, executive function and memory, to autism:http://www.jlr.org/cgi/reprint/M400486-JLR200v1.pdf
Quote:
Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer disease
Roger M. Lane, MD* and Martin R. Farlow, MD. Publ. in Journal of Lipid Metabolism 2005
“In addition, it has been proposed ( Henderson S. T. 2004 Med. Hypotheses ) that the inhibition of lipid metabolism by high carbohydrate diets may be the most detrimental aspect of modern diets. AD may be similar to obesity, coronary artery disease (CAD) and type II diabetes mellitus in being a consequence of the conflict between our Paleolithic genetic constitution and our current Neolithic diet.
Roger M. Lane, MD* and Martin R. Farlow, MD. Publ. in Journal of Lipid Metabolism 2005
“In addition, it has been proposed ( Henderson S. T. 2004 Med. Hypotheses ) that the inhibition of lipid metabolism by high carbohydrate diets may be the most detrimental aspect of modern diets. AD may be similar to obesity, coronary artery disease (CAD) and type II diabetes mellitus in being a consequence of the conflict between our Paleolithic genetic constitution and our current Neolithic diet.
Happy hunting.
It's fascinating stuff!
.
Last edited by ouinon on 15 Aug 2009, 10:39 am, edited 3 times in total.
