XXYY Syndome and Klinefelter's

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LK
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09 Feb 2010, 7:56 pm

I am curious to know if any of you, who have been diagnosed with an ASD have been tested for XXYY, XXY, or similar disorders.

Or, do any of you have a diagnosis of XXYY or Klinefelters syndrome?

Thank you.

ASdogGeek
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09 Feb 2010, 11:04 pm

No I am sorry I haven't and isn't klienfelters deadly?

BrooxBroox
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09 Feb 2010, 11:44 pm

I have a cousin with XYY (Jacob's Syndrome). He's extremely tall with severe acne and his "mental age" is 9 years old, but physically he is a 44-yr-old man.

CMaximus
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09 Feb 2010, 11:45 pm

A guy in my ASD meetup does.

Sedaka
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10 Feb 2010, 10:40 am

Doubt it's correlated to ASDs... But being sexy creatures, we're all subject to a little scrambling in that area.

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Callista
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10 Feb 2010, 11:20 am

It is, actually. Klinefelter folks get diagnosed at an increased rate; but that doesn't surprise anybody who knows about chromosomal disorders--just about any group of people with odd chromosomes is on the spectrum more often than general population.

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Last edited by Callista on 10 Feb 2010, 11:21 am, edited 1 time in total.

starygrrl
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10 Feb 2010, 11:20 am

Sedaka wrote:

Doubt it's correlated to ASDs... But being sexy creatures, we're all subject to a little scrambling in that area.

Actually it does. Klinefelter's syndrome (XXY) is one of the few areas where there is a definite genetic correlation. Most individuals with klinefelter's have AS. In fact it is so pervasive, that ASD traits are listed in the traits for Klinefelter's. It is one of the few genetic links there is out there relating to autism.

I will note, I have an intersex syndrome, but I do not have klinefelter's. I just know alot about Intersex syndromes and co-morribund conditions created by them. Autism Spectrum Disorders, Learning Disabilities and other neurological issues are very common with intersex syndromes across the board. So there is a link, if your body is not genetically disposed to processing hormones correctly, it does have a neurological impact in addition to the physical impact.

sartresue
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10 Feb 2010, 4:29 pm

Other syndromes topic

The physical and mental manifestations of extra/missing chromosomes is a special interest of mine. Fascinating

Another thread here on Klinefelter's:

Klinefelter thread.

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Last edited by sartresue on 11 Feb 2010, 8:57 am, edited 1 time in total.

LK
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10 Feb 2010, 5:22 pm

ASdogGeek, Klinefelters is not deadly... www.klinefeltersyndrome.org

Thank you for explaining, Callista and Starygrrl.

Lyn
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21 Feb 2010, 5:10 pm

My son has XXYY Syndrome. From the most recent research, about 30% of boys and men diagnosed with XXYY Syndrome are also diagnosed somewhere in the autism spectrum. This is much higher than in the general population. Klinefelter Syndrome has a much lower rate of ASD. Here are a couple of links that will tell you all about XXYY Syndrome and Klinefelter Syndrome.

xxyysyndrome. org
genetic. org

LostInSpace
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21 Feb 2010, 5:57 pm

No, but I knew an autistic boy with Klinefelter's.

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Tysse
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16 Nov 2010, 12:09 am

I'm intersexed.

Mike_GX1
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28 Dec 2012, 10:32 am

Please note that a newer, more up-to-date (and more accurate) discussion has developed on this subject elsewhere on this forum - please access it using the following link:
Klinefelter's Syndrome
Thanks

Pompeji
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31 May 2014, 6:37 pm

starygrrl wrote:

Sedaka wrote:

Doubt it's correlated to ASDs... But being sexy creatures, we're all subject to a little scrambling in that area.

So there is a link, if your body is not genetically disposed to processing hormones correctly, it does have a neurological impact in addition to the physical impact.

That's a quite interesting conclusion. It would also fit into the picture that testosterone subsitution has not any (reported) effects on ASD traits with XXY males.

Pompeji
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03 Jun 2014, 7:56 pm

there is a relatively new paper on this topic, e.g.

ncbi.nlm.nih . gov/pubmed/24655419 (still waiting for full text)

and there is plenty of information linking both syndromes:

Quote:

Many of the education needs of boys with KS are similar to those of boys with Asperger's Syndrome. Ironically, most parents struggle to get a statement for their KS boys, whose diagnosis is a simple blood-test, because education authorities quote the few boys who get through the system without help, yet ignore the thousands who fall by the wayside with needs they can see every day in boys with more "acceptable" syndromes. Remember, that just because your son has a KS diagnosis it doesn't mean he doesn't have something else too! In the KSA we have many, many parents whose sons have been refused a statement several times, then later on found out that he also has something that, if named earlier, would have got him the support almost as a matter of course. Asperger's Syndrome is just such a condition that lies beneath the raft of symptoms shown by KS boys - many of the education needs are similar, most of the boys, it seems are investigated for the condition prior to diagnosis.

ksa-uk . net /links/53-ksa-links-resources

see also:

Brandenburg-Goddard MN. et al., A comparison of neural correlates underlying social cognition in Klinefelter syndrome and autism, Soc Cogn Affect Neurosci. ,2014,1-8
Cederlöf M. et al., Klinefelter syndrome and risk of psychosis, autism and ADHD, Journal of Psychiatric Research 48 (2014), 128-130)
van Rijn S. et al., Social Behaviour and autistic traits in a sex chromosomal disorder: Klinefelter (47 XXY) syndrome, J Autism Dev Disord, 2008, 38: 1634-1641
van Rijn et al., Neural systems for social cognition in Klinefelter syndrome (47,XXY): evidence from fMRI, SCAN (2012) 7, 689-697
van Rijn et al., Social attentation, Affective Arousal and Empathy in Men with Klinefelter Syndrome (47,XXY): Evidence from Eyetracking and Skin conductance, PLoS One, 2014, 9 (1): e84721

neobluex
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03 Jun 2014, 9:05 pm

[Haven't been tested for ASD nor Klinefelter's]

I have the signs of Klinefelter's syndrome, except for the sparse facial/body hair (I have a lot).

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