Even when I was very severely depressed I still kept mine, in fact it was pretty much the only thing I still did. I was suicidal, my sleeping and eating patterns went out of the window, I did no housework, had no contact with any friends, became very paranoid (although not in a conspiracy theory type way) and heard voices, barely left the house due to severe anxiety issues, had shutdowns where I could not speak and would just sit and stare (and sometimes cry), cried over anything and nothing etc. but I would still play Civilization (my passion at the time, my special interest changes from time to time) for a few hours a day.