Although I haven't been in high school since the nineties, and was not diagnosed at the time, looking back I can honestly say that English class was the worst for me. This is despite always having been highly articulate, grammatically sound and enjoying reading for the most part and yes even Shakespeare. Looking back now, it all makes sense. The downfall for me was attempting to grasp metaphors, and abstract concepts, including foreshadowing and symbolism. I believe this also goes hand-in-hand with not intuitively picking up on key elements in a movie plot, or for that matter just not getting subliminal messages and subtexts as neurotypicals do - it's just not part of our "default program".
It all reached a boiling point in my last year of high school, at 18 years old, I really rubbed an English teacher the wrong way who became openly hostile towards me. He basically insisted that there was NO WAY that I couldn't understand the abstract concepts that others were absorbing without breaking a sweat, by this point. He insisted that I was bamboozling him (his own word, not mine!) and that I was being passive-aggressive and should shape up before I enter the real world because my "attitude" wouldn't be tolerated there. I got a C+ in the course, the lowest of all of them. I'd switched schools in my last year, so the record of my progress wasn't as apparent at the new school I suppose. But then again, neither was the diagnosis/condition of Aspergers.
Yet despite my attempts to try to figure things out, to make sense of where I was going wrong by approaching him with what I believed was genuine concern, he responded negatively - he raised his voice at me (to a moderate level, but noticeable even for me) and a couple of times I could swear that he was trembling on the inside with rage. Yes, odd how I noticed that given my nonverbal challenges, but I did, I guess it spoke to how frustrated the teacher truly was.
I'm sure today though, there is more remedial support for learning such abstract concepts in literature for those of us with AS.