Most interviewers are not trained to do it and are nervous themselves, trying to fill the amount of time that they are supposed to fill. Thats why they will sometime do alot of the talking themselves. I've been on both sides.
I have had a couple tough interviews, but mostly easy. They hardly ever ask you anything technical or anything relating to the job itself, just small talk stuff. I can see how this could be tough for most aspies, but myself, I have learned how to fake it through that kind of stuff. Before going in, think of one or two things that you like to do that are at least slightly normal. They don't have to be super-normal, it is actually good if the interviewer is unfamiliar with your chosen leisure activity. I pick disc-golf, even though I hardly play anymore. Most people don't know a lot about it, so I can take about 5 minutes just describing what disc-golf is. Then when they ask you what you like to do, or ask you to describe yourself, just talk about your one or two prechosen subjects. By the way, "Tell me about yourself" is a terrible interview question. People should be embarressed to ask something so generic.
The worst interview I ever had, somewhat ironically, was for a job at a Six Flags themepark (big franchise of amusement parks here in the states). I say ironically because, at the time, I was close to graduating with a degree in engineering, and most of the people they interview are high school kids, and not necesarily the brightest high school kids. I think the interview was tough because the questions probably came out of some interview handbook. They were very generic, but were made to be kind of challenging. Things like, "Tell me about a time that you overcame a challange" and stuff like that. In other interviews, I had been able to get through those kinds of questions, but for some reason, that time I was just a mumbling idiot. I could tell I was making the interviewer uncomfortable, and the interview was probably over in like 10 minutes, since I could hardly think of anything to say.