I think part of this could come from trauma and being hyper vigilant. We might be feeling unprepared for interactions with others, or associate emotional or physical trauma with interactions due to past experience. I became very defensive and sensitive to comments and behavior of others as a sort of self defense mechanism. What helped me was learning healthy self assertive behavior. Once I had the tools to defend myself in verbal interactions and understood about being manipulated through aggression, social pressure, guilt, etc etc, I noticed a lot of the hyper sensitive behavior went away. I think for me, it was a sort of response to feeling helpless in so many situations where I had not learned the way to set boundaries, to say no, and to recognize and defend myself against unhealthy behavior of others. I got therapy and the therapist used a book called "when I say NO I feel guilty" by Manuel J Smith. There are lots of websites and books about learning to be self assertive in healthy ways. It gets easier and better with practice. The book probably saved my life and sanity. If you don't think you can do it alone, find a therapist/ life coach to help you. I had to have a lot of things explained to me because I was not able to sort it out on my own. ( probably autism involved there, that's OK). Sending best wishes