Superbug crisis could get worse

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The number of lives lost around the world due to infections that are resistant to the medications intended to treat them could increase nearly 70% by 2050, a new study projects, further showing the burden of theongoing superbug crisis.

Cumulatively, from 2025 to 2050, the world could see more than 39 million deaths that are directly attributable to antimicrobial resistance or AMR, according to the study, which was published Monday in the journal The Lancet.

Antimicrobial resistance happens when pathogens like bacteria and fungi develop the ability to evade the medications used to kill them.

The World Health Organization has called AMR “one of the top global public health and development threats,” driven by the misuse and overuse of antimicrobial medications in humans, animals and plants, which can help pathogens develop a resistance to them.

The new study reveals that when it comes to the prevalence of AMR and its effects, “we expect it to get worse,” said lead author Dr. Chris Murray, director of the Institute for Health Metrics and Evaluation at the University of Washington.

“We need appropriate attention on new antibiotics and antibiotic stewardship so that we can address what is really quite a large problem,” he said.

Older adults bear the burden

The researchers – from the Global Research on Antimicrobial Resistance Project, the Institute for Health Metrics and Evaluation and other institutions – estimated deaths and illnesses attributable to versus associated with antimicrobial resistance for 22 pathogens, 84 pathogen-drug combinations and 11 infections across 204 countries and territories from 1990 through 2021. A death attributable to antimicrobial resistance was directly caused by it, while a death associated with AMR may have another cause that was exacerbated by the antimicrobial resistance.

About 520 million individual records were part of the data to make those estimates.

The researchers found that from 1990 to 2021, deaths from AMR fell more than 50% among children younger than 5 but increased more than 80% among adults 70 and older – trends that are forecast to continue.

It was surprising to see those patterns emerge, Murray said.

“We had these two opposite trends going on: a decline in AMR deaths under age 15, mostly due to vaccination, water and sanitation programs, some treatment programs, and the success of those,” Murray said.